in order to re-create a new immune system

December 7, Huaihua,nike tn pas cher, China's first AIDS Care Center - Hongjiang district care center. Laohong care center (a pseudonym) in funny kids play. Young lyric photo
Timothy Ray Brown (Timothy & nbsp; Ray Brown) must be the most compelling in 2010 patients.
 
Everything about him was very mysterious, very few people know his hair color, possessor of any pets at home, or like what movie star. Nevertheless, the media coverage around the world are living in Berlin this 42-year-old white man. He had been a full 10 years of AIDS entangled. December 8, the seven-member team consisting of three universities in Germany of Medicine study published online staff paper said, "Our findings show that the patient has been cured of AIDS," the well-known scientific journal "Blood."
 
Since HIV was discovered in 1981, in the "Century killer" to kill as many as 60 million people in the list, Brown may be the first and currently the only person to be cured. The German patient is considered cured "stunning breakthrough."
 
When the treatment of leukemia cure AIDS
 
Miracles happen in a red brick building, which is located in the German capital of Charlotte's Hospital,air max pas cher homme, is the largest university hospital in Europe.
 
Brown is old and sick in the hospital. Since 10 years ago was diagnosed with AIDS, he has been receiving drug treatment here. Virus did not defeat this middle-aged man's body, but has been quietly lurking in his body.
 
AIDS Research Center at Tsinghua University, Professor Zhang Linqi opinion, this is a terrible place to HIV. If the cells are seen as a wallet,basket nike pas cher, this virus is like a robber. Under the microscope, this seems like a "small stab the ball," the virus, it will break the "treasury" door "security code", rushed into the interior of the cell. Then, it will mark its own integrated into the chromosome of the innermost cells, become part of the cell.
 
Today, dangerous people who brought about this robbery is no longer strange, it will attack the body's immune system is the most important T4 lymphoid tissue. Once the immune tissue collapse, people's resistance becomes low, it is very likely due to infection and death.
 
Looters might lurk in a patient over 10 years. So, when people drug "police" to send the patient when infected, it is often difficult to track down these quietly hidden villain.
 
Brown has been living under the shadow of these robbers. Meanwhile,http://xymcw.hncywl.net/bbs/home.php?mod=space&uid=27068, another terrible disease and quietly wrap him. A few years ago,http://www.rockclimbing.com/cgi-bin/routes/page.cgi, the hapless man diagnosed with leukemia. Under the two "incurable disease" in the attack, it seems, he almost lost the possibility to survive.
 
However, Charlotte hospital clinicians director Eckhard Thiel (Eckhard & nbsp; T & nbsp; hiel) did not give up,http://bbs.mdtmw.com/forum.php?mod=viewthread&tid=1719218, the main hematology and oncology doctors decided to conduct a bold attempt. In the mid-90s of the last century, American scientists have found that some people will not be born with HIV infection. Steele and his colleagues began to think, if it finds a "born from HIV-infected persons," with Brown matching bone marrow donor, and "in the treatment of leukemia with a bone marrow transplant, the patient is not HIV also will follow along with it disappear? "
 
In fact, in ordinary cells, "treasury", most of the set up two "security code",air max femme pas cher, one is called CD4, another one were called CCR5. But for HIV, it is very easy to crack passwords groups,http://www.antweb.org/cgi-bin/mt/mt-search.cgi, the so-called security measures useless.
 
But in those born to HIV "immune" lucky cells, due to mutations, CCR5 gene coding region of 185 amino acids after No. 32 base deletion occurs. This is called the defective gene CCR5 △ 32 is equivalent to the vault encryption, regardless robbers resorted to what tricks can not sneak into the vault.
 
Brown is very fortunate for Brown in 60 bone marrow transplant donors,http://www.fantem.com/phpwind/read.php?tid=3070626&ds=1,polo ralph lauren pas cher,http://www.prco.jp/~shake/apeboard/apeboard_plus.cgi?command=viewres&target=166360/, the research team found a man with a CCR5 △ 32 gene for him. In February 2007, when Brown undergo the transplant, the donor's bone marrow in his body began operations began to produce new blood cells.
 
Like doctors had envisioned it, the newly generated cells have defective gene CCR5 △ 32. After 3 years of follow-up investigation, the doctors are convinced a miracle happened, "HIV in the patient's body completely disappeared."
 
In this we did not even dare mention aloud "cure" in the field of the word, this is definitely enlightening discovery
 
Just over a year ago, as the case written papers published in prestigious medical profession in the world, "New England Journal of Medicine." At that time, the research team from Germany is cautioned that "long-term control by bone marrow transplantation for HIV." Zhang Linqi remember this case the whole field of science "very shocked."
 
Prior to that paper was published, this terrible virus has been called "the history of centuries after the plague." HIV is known as the world's "number one infectious killer", there are 200 million people have died each year.
 
World Health Organization also wrote his own official website, if you insist on treatment, "HIV-infected individuals can remain in good condition, maintaining the ability to work to extend the life time, even in low-income countries, HIV-infected individuals can do." However, WHO is also categorically said: "HIV can not be cured."
 
Therefore, when Brown could not find the body of HIV whereabouts, Reuters wrote in the report, in this "we did not even dare mention aloud 'cure' word in the field, this is definitely enlightening discovery." .
 
Although this is a "incurable" disease, but research it has not run aground. Currently, antiviral treatment can prolong the life of 30 to 50 years, compared with the life expectancy of a complete cure is only 10 years earlier.
 
90s of last century, the Chinese scientist David Ho made the famous "cocktail therapy", ie to use several drugs,http://www.kyoto-oasc.jp, each drug against HIV reproductive cycle in different sectors, so as to inhibit or kill HIV purposes.
 
November this year, an article published by the University of California, San Francisco research team in the "New England Journal of Medicine," the paper said, antiretroviral drugs may reduce the risk of infection and the spread of AIDS rate to some extent, "it first once again proved regular medication can partially reduce HIV in gay and bisexual men at high risk of the propagation speed. "
 
Served as an assistant in the United States Zhang Linqi Ho found that although the drug can inhibit new cells are infected, but has been infected cells but can survive for long periods in vivo. These viruses lurking quietly, causing the drug or simply can not find. This became the "biggest obstacle to cure AIDS."
 
He put HIV as a "microcosm of Superman", although only a few 100 nanometers in diameter, but it is a "formidable opponent."
 
A few years ago, this has been beaten for 19 years and AIDS dealings "returnees" Professor decided to start the development of an AIDS vaccine. Now, in laboratory animal experiments, the vaccine has produced a "very good observation."
 
In July,http://www.idyllarbor.com/research/search.cgi, the US National Institute of Allergy and Infectious Diseases experts published research on "Science" journal, said the discovery of two can "bind" and hit more than 90 %% variant strains of HIV antibodies.
 
However, this does not mean that the vaccine will soon be put into production. Zhang Linqi said: "Although the direction is clear, but how long the road, who knows."
 
When Brown was cured of the news, those who believe that "it is impossible to cure a disease," the scientists were very excited. This proves the conjecture before the medical profession, "If the use of genetic means to CCR532 base knock on the cell surface, so the body of HIV-infected persons can be completely removed."
 
Some European and American scientists are ready to encourage CCR5 △ 32 type of people to donate bone marrow, and find a suitable matching in HIV-infected individuals worldwide. They excitedly told desperate patients, "Do not worry, AIDS can be cured."
 
Fortunately, it is not easy to copy Brown
 
However, Brown's lucky you want to copy is not an easy task. In Zhang Linqi view, the German patients were cured in the process, just like "lightning struck several times in a row of small probability event." An HIV-infected patients with leukemia, one pair for HIV "immunity" of bone marrow matching, one can afford to pay huge medical expenses wallet, these elements are indispensable.
 
At least, a Chinese patient is difficult to accomplish this, because few people have the yellow gene CCR5 △ 32 people. In the 100 Europeans, and only one person has the ability to protect this highly mutated genes.
 
AIDS virus before the American Medical Association president Zag that "if this approach become standard therapy, there is a great risk."
 
Currently, stem cell or bone marrow transplant commonly used in cancer treatment, but no one knows if healthy people need to take much of the risk of accepting this surgery. It involves the use of powerful drugs and radiation destroy the body's immune system to the original, and then enter the donor's bone marrow, in order to re-create a new immune system, and lead to complications of the therapy is likely to increase mortality.
 
"This method is not practical, and it is possible to kill people." Dr. Gallo human viruses, University of Maryland, said. 26 years ago, it was his work that scientists and partners discover the HIV virus. "I do not want to pour cold water on this interesting things, but, you know, this is, at best, just a funny thing. And, until the dead, carried out a detailed examination, in order to fully determine the virus completely disappeared."
 
For Zhang Linqi, the "science of unpredictability too, when things start to look only fun, but in the end it could bring milestones."
 
His former colleagues Paxton is a good example. That is also a gay virologist. The mid-90s of the last century, out of curiosity, his own blood around some gay friends were detected. The result was a surprise, some people are easily infected with HIV, while the other part will not be infected.
 
Scientists have found a CCR5 △ 32 on an experimental basis on Paxton. And it is more than ten years ago that the experiment was carried out of curiosity, Brown saved the patient's life in Germany.
 
"Scientific development can not step away possible cure for AIDS is still a long way, but at least now taken the first step." Zhang Linqi said. For the long engaged in HIV research professor who, this peculiar German patients demonstrated at least a little, if we can knock down CCR5 32 bases in the body, there is a possibility to cure AIDS.
 
"On the basis of scientific research, the plan never catch up with rapid change, no one can say for sure, what is at what moment, in which the laboratory, this study will be successful." He said seriously.